Section 1: Historical Perspectives. - 1 History and Basic Properties of the Muscarinic Cholinergic Receptors. - Section 2: Pharmacological Properties Purification and Cloning of Muscarinic Receptors. - 2 The Binding Properties of Muscarinic Receptors. - 3 Muscarinic Receptor Purification and Properties. - 4 Subtypes of Muscarinic Cholinergic Receptors: Ligand Binding Functional Studies and Cloning. - 5 Structural Determinants of Muscarinic Agonist Activity. - Section 3: Biochemical Effectors Coupled to Muscarinic Receptors. - 6 Muscarinic Cholinergic Receptor-Mediated Regulation of Cyclic AMP Metabolism. - 7 Muscarinic Cholinergic Receptor Regulation of Inositol Phospholipid Metabolism and Calcium Mobilization. - 8 Muscarinic Receptor Regulation of Cyclic GMP and Eicosanoid Production. - 9 Muscarinic Cholinergic Receptor Regulation of Ion Channels. - Section 4: Regulation of Muscarinic Receptors. - 10 Allosteric interactions of Muscarinic Receptors and Their Regulation by Other Membrane Proteins. - 11 Regulation and Development of Muscarinic Receptor Number and Function. - Section 5: Future Directions. - 12 Future Directions. Language: English