of Volume 7. - 1 Genetic Factors in Alcohol Abuse: Animal Models. - Animal Models in Alcohol Research. - A Quantitative Genetic Model. - Genetically Defined Populations in Alcohol Research. - Selective Breeding. - Summary. - References. - 2 Genetic Factors in Alcoholism. - Common Methodological Problems in Research on Genetic. - References. - 3 Acute Pharmacological Actions of Ethanol on the Central Nervous System. - Membranes. - Effects of Ethanol on Brain Calcium. - Membrane-dependent Neurotransmitter Activity. - Summary. - References. - 4 Ethanol and Brain Mechanisms of Reward. - Substrates of Brain Stimulation Reward. - Substrates of Drug Reward. - Interactions of Drugs of Abuse with Brain-Stimulation Reward. - Speculations. - References. - 5 Ethanol as a Reinforcer: Comparison with Other Drugs. - Intravenous Drugs as Reinforcers. - Intragastric Drug Self-administration. - Ethanol and Other Drugs as Reinforcers by the Oral Route. - Summary and Conclusions. - References. - 6 A Behavioral Analysis of the Reinforcing Properties of Alcohol and Other Drugs in Man. - Behavioral Effects of Alcohol and Drugs. - Control of Behavior by Aversive Consequences. - Substance Abuse: Similarities and Differences. - Conclusions. - References. - 7 Neurochemical Aspects of Tolerance to and Physical Dependence on Alcohol. - Definitions of Functional Tolerance and Dependence. - Factors Modulating Ethanol Tolerance Development. - Effects of Ethanol Administration on Neurotransmitters. - Neurotransmitter Receptors. - Role of Neuronal Membranes in Development of Tolerance and Dependence. - Role of Condensation Products in Ethanol Tolerance and Dependence. - Conclusions. - References. - 8 Metabolic Mechanisms in Tolerance and Physical Dependence on Alcohol. - Metabolic Tolerance. - Metabolism Mechanisms in Physical Dependence. - References. - 9 Endocrine Mechanisms in Tolerance to and Dependence on Alcohol. - Alcohol-Endocrine Interactions. - Conclusions. - References. - 10 The Relationship of Tolerance and Physical Dependence to Alcohol Abuse and Alcohol Problems. - A Consideration of the Regulation of Alcohol Consumption. - Tolerance. - Physical Dependence. - Implications for Prevention and Treatment. - Conclusion. - References. - 11 Brain Dysfunction and Alcohol. - Structural Brain Damage. - Evoked Potentials. - Concluding Remarks. - References. - 12 Cognitive Deficits in Alcoholics. - Short-term Effects of Alcohol Ingestion. - Long-term Effects of Alcohol Ingestion. - Theoretical Considerations. - References. - 13 Prenatal Effects of Alcohol Abuse in Humans and Laboratory Animals. - Historical Introduction to Alcohol Abuse in Pregnancy. - Intrauterine Effects of Maternal Alcohol Abuse in Humans. - Animal Models of Maternal Alcohol Use and Abuse. - The Importance of Fetal Alcohol Syndrome to Problems of Female Alcohol Abuse. - Conclusions. - References. - 14 Amethystic Agents in the Treatment of Alcohol Intoxication. - Available Antagonists of Centrally Active Drugs. - Putative Alcohol Antagonists. - Conclusions and Recommendations for Future Study. - References. Language: English