Short-Term Tests for Chemical Carcinogens

Viral Systems. - 1. A Biochemical Phage Induction Assay for Carcinogens. - 2. Detection of DNA-Modifying Agents by Analyzing the Lesions Introduced into Purified PM2 DNA. - 3. Reactivation of Viruses. - DNA. - 4. Metabolic Activation of Nitroheterocyclic Compounds in Bacteria and Mammalian Cells. - 5. Utilization of the Alkaline Elution Assay as a Short-Term Test for Chemical Carcinogens. - 6. DNA Synthesis Inhibition in Mammalian Cells as a Test for Mutagenic Carcinogens. - 7. DNA Repair Synthesis (UDS) as an in vitro and in vivo Bioassay to Detect Precarcinogens Ultimate Carcinogens and Organotropic Carcinogens. - 8. Multi-well Assay for Unscheduled DNA Synthesis Using Human Diploid Fibroblasts. - 9. Sucrose Gradients: An Assay for DNA Damage. - 10. The Testicular DNA-Synthesis Inhibition Test (DSI Test). - Microbial Systems. - 11. The Salmonella Mutagenicity Test: An Overview. - 12. Applications of the Salmonella/Microsome Assay. - 13. Determination of Genotoxic Activity Using DNA Polymerase-Deficient and -Proficient E. coli. - 14. The Nucleotide-Permeable Escherichia coli: A Model System that Responds to DNA-Binding Carcinogens Mutagens and Antitumor Agents with DNA Excision Repair or with Inhibition of Replicative DNA Synthesis. - 15. The Yeast Saccharomyces cerevisiae: An Assay Organism for Environmental Mutagens. - 16. Induction and Genetic Characterization of Specific Locus Mutagens in the ad-3 Region in Two-Component Heterokaryons of Neurospora crassa. - 17. Neurospora and Environmentally Induced Aneuploidy. - Higher Plants. - 18. Plant Genetic Test Systems for the Detection of Chemical Mutagens. - Chromosomes. - 19. A Short-Term Cytogenetic Test for Genetic Instability in Humans. - 20. The Sister Chromatid Exchange Test. - 21. The Micronucleus Assay. I. In Vivo. - 22. The Micronucleus Assay. II. In Vitro. - 23. Automation in Cytogenetics. - Mammalian Systems. - 24. Mutagenesis Studies in Diploid Human Cells with Different DNA-Repair Capacities. - 25. Liver Culture Indicators for the Detection of Chemical Carcinogens. - 26. An Escherichia coli Differential Killing Test for Carcinogens Based on a uvrA recA lexA Triple Mutant. - 27. Detection of Carcinogens Using the Fluctuation Test with S9 or with Hepatocyte Activation. - Transformation. - 28. In Vitro Mammalian Cell Transformation for Identification of Carcinogens Cocarcinogens and Anticarcinogens. - 29. The Use of Cryopreserved Syrian Hamster Embryo Cells in a Transformation Test for Detecting Chemical Carcinogens. - 30. Assay of Chemically Induced Transformation of Human Cells. - 31. Chemical-Viral Interactions: Enhancement of Viral Transformation by Chemical Carcinogens. - 32. The Calcium Independence of Neoplastic Cell Proliferation: A Promising Tool for Carcinogen Detection. - Entire Animals. - 33. Induction of a Resistant Preneoplastic Liver Cell as a New Principle for a Short-Term Assay in vivo for Carcinogens. - 34. Recent Achievements with Drosophila as an Assay System for Carcinogens. - 35. Strategy for Breeding Test Animals of High Susceptibility to Carcinogens. - 36. Methods for Human and Murine Sperm Assays. - Cocarcinogens Anticarcinogens and Promoters. - 37. In vitro Assay for Tumor Promoters. - 38. Inhibition of Chemical Mutagenesis: An Application of Chromosome Aberration and DNA Synthesis Assays Using Cultured Mammalian Cells. - 39. Detection of Cocarcinogens and Anticarcinogens with Microbial Mutagenicity Assays. - 40. The Use of A Bacterial Assay to Identify Which Agents Modify Carcinogen-Induced Mutagenesis. - Concepts. - 41. Quantitative Measures of Induced Mutagenesis. - 42. Tests for PotentialCarcinogens: Unresolved Problems. - 43. Mutagenicity Testing: Problems in Application. - 44. Short-Term Genetic Tests Extended to the Human. Language: English