SAMe (S-adenosyl methionine) is an amino acid derivative used by the body in three main ways: methylation, polyamine synthesis, and trans-sulfuration (synthesis of cysteine, glutathione, and other sulfates). It is required for the synthesis of norepinephrine, dopamine, and serotonin, and plays a role in other intracellular metabolic pathways. SAMe facilitates the use of glutathione and regulates acetylcholine levels. In this way, it also contributes to improving or maintaining cognitive function and mitigating or preventing aging and neurodegeneration. Recent discoveries have demonstrated the effectiveness of SAMe in maintaining stable mood and joint function, without side effects. SAMe addresses various problems that people face as they age, such as joint discomfort and immobilization. It also offers multiple mechanisms of action that are used throughout the body, especially the liver, and that help keep it healthy. Take 1 tablet one to three times daily in divided doses, preferably on an empty stomach, or as recommended by a healthcare professional. Take with cofactors such as vitamins B12, B6, and folic acid. SAMe should not be taken by those diagnosed with bipolar disorder. Keep out of reach of children. Do not exceed the recommended dose. Do not purchase if the outer seal is broken or damaged. A food supplement should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. Store tightly closed in a cool, dry place.