Topic I. The Influence of Antigen Upon the Conformation of Antibody. - Antibody-Hapten Binding Kinetics Conformational Transitions and Domains Interactions. - Dynamic Aspects of Signal Transfer in Antibody Molecules. - Could Aggregation of Human Immunoglobulins Bring About Appearance of Novel Antigenic Sites?. - Topic II. Structure/Function Interrelationships in IgM and IgG. - Immunoglobulin M Conformational Change is a Signal for Complement Activation. - Expression of Fc Effector Function in Homogeneous Murine Anti-ARS IgM. - The Localization of Effector Sites on Immunoglobulin G. - Human Fc? Fragment: Location of Acidic Residues Involved in Complement Activation. - Topic III. Structure Of C1 Interactions Between its Subunits and Other Macromolecules. - Ultrastructure of the First Component of Human Complement. - Binding of Human 125I-Fibronectin to C1q and to Human Monoclonal Myeloma IgG Subclasses. - Biochemical Specificity of Human Complement Component C1q. - Sequence Studies on Human Complement Subcomponent C1r. - Topic IV. The Activation of the First Component of Complement. - Dissociation of C1 and Concentration Dependence of Its Activation Kinetics. - Fluid Phase Activation of Proenzymic C1r. - Activation of Mammalian Complement by Chicken C1q. - Topic V. The Importance of Antigen Conformation for Antigenicity and Immunogenicity. - Conformational Antigenic Determinants in Proteins. - Topographic Antigenic Determinants Detected by Monoclonal Antibodies to Myoglobin. - Role of Conformation on the Antigenic Determinants of Tobacco Mosaic Virus Protein. - Monoclonal Antibodies May Block Sterically or Conformationally the Antigenic Determinants of Human Growth Hormone. - An Immunochemical Study of the Changes in Conformation Undergone by Two Domains of the Tryptophan-synthetase ?2Subunit upon Association. - Topic VI. The Changes in Protein Antigen Conformation Induced by Antibody. - Antibody-mediated Activation of Genetically Defective Escherichia coli Galactosidases by Monoclonal Antibodies. - Synergistic Activation by Monoclonal Antibodies of ?-galactosidase from Genetically Defective E. coli. - Antibodies as Probes of Protein Structure. - Is There a Preferential Pathway for Antibody-mediated Enzyme Activation?. - Topic VII. The Recognition by T Cells of Protein Antigens. - General Introduction. - VIIa. Which are the Antigenic Determinants that T Cells Recognize?. - T Lymphocyte Recognition of Small Peptide Antigens: Formation of Neoantigenic Determinants and Clonal Frequency Resulting in Ir Gene Control. - The Antigenic Structure of Bovine Serum Albumin: T-Cell B-Cell and Ia Determinants. - Attempts to Understand the Function of Macrophages and Antigen Specific Cells in their Mutual Interaction. - A Possible Immunodominant Domain on Myoglobin Recognized by T Lymphocytes. - VIIb. What is the Role of MHC and Other Genes in the Antigen-presenting cell?. - Antigen Presenting Function of Macrophages. - The Sorting-Out Problem in Antigen Presentation. - Genetic Analysis of Responsiveness to Adjuvant-Free Immunological Signals: Transfer of Genes from Responder Strains (SJL/J and CE/J) to a Nonresponder Background Uncovers a Requirement for H-2 Heterozygosity. - How is Adjuvanticity Recognised?. - VIIc. Analysis of the Ternary Complex of Antigen: MHC: and T-cell Receptor with T cell Clones. - Specificity and Restriction of T Cells in a System of Complementing Ir Genes. - Evidence for Ia-Antigen Interaction in T Cell Activation. - Somatic T Cell Hybrids in the Analysis of H-2 Restriction and Antigen Recognition. - Topic VIII. Structural Aspects of T-B and T-TInteraction. - Antigen Bridging in T Cell-B Cell Interaction: Fact or Fiction?. - B Cells as MHC Restricted Antigen Presenting Cells: A Model for T-B Interaction. - A View from the Bridge: Antigenic Determinants in Immunoregulation. - Antigen Structures Used by Regulatory T Cells in the Interaction Among T Suppressor T Helper and B Cells. - Activation of Human B Lymphocytes by Antigen Specific T Cell Lines. - T Helper Cell Recognition of Two Types of Mouse Lambda Light Chains. - Effects of Anti-Idiotypic Sera (Ab-2) and Monoclonal Idiotypic Antibody (Ab-1) on the Immune Response to a Simple Polypeptide Antigen with only two Immunologically Active Epitopes. Analysis of the Response at the Unideterminant Level. - Topic IX. Effector Mechanisms for Cell Signaling Resulting from Antigen-Antibody Interactions. - The Role of IgE and its Receptor in Mediating Secretion. - A New Method for Monitoring Intracellular Free Ca2+ in Lymphocytes. Concanavalin A and Anti-Igm Induce an Early Rise of Cytoplasmic Free Ca2+. - B Lymphocyte Stimulation and Suppression by the Fc Portion of Immunoglobulin. - Modulation of Immunological Reactivity by the Fc Piece of Immunoglobulin. - T Cell Replacing Factor (TRF)-Induced IgG Production in a Human B Cell Line and the Mechanism of Transmembrane Signaling through TRF-Acceptors. Language: English