1. The Molecular Biology of the NaK-ATPase and Other Genes Involved in the Ouabain-Resistant Phenotype. - 1. Introduction. - 2. Molecular Cloning of the NaK-ATPase Catalytic Subunit. - 3. Organization and Expression of the Rat Sodium Pump a-Subunit Gene. - 4. Organization and Expression of the a-Subunit Gene in Ouabain-Resistant Cell Lines. - 5. Isolation and Characterization of a Ouabain-Resistance Gene. - 6. Transfer of the Sodium Pump a-Subunit Gene Confers Ouabain Resistance to Ouabain-Sensitive Cells. - 7. Isolation of Genes Related to the Sodium Pump and Their Expression in a Ouabain-Resistant Cell Line. - 8. Conclusions and Future Prospects. - References. - 2. Molecular Biology of the Genes Encoding the Major Myelin Proteins. - 1. Introduction. - 2. Formation and Structure of the Myelin Sheath. - 3. Myelin-Specific Proteins. - 4. Conclusion. - References. - 3. Molecular Biology of the Neural and Muscle Nicotinic Acetylcholine Receptors. - 1. Introduction. - 2. Isolation of cDNA Clones Coding for the Acetylcholine Receptor Expressed in the Torpedo Electric Organ. - 3. Isolation of cDNA Clones Coding for Mouse Skeletal Muscle Acetylcholine Receptor. - 4. Structure of the Acetylcholine Receptor. - 5. Expression of the Acetylcholine Receptor Genes in Skeletal Muscle. - 6. Brain Receptors. - 7. Conclusion. - References. - 4. Molecular Biology of Muscle Development: The Myosin Gene Family of Caenorhabditis elegans. - 1. Introduction. - 2. Genetics of the unc-54 Locus. - 3. Immunological Identification and Localization of Myosin Isoforms. - 4. Molecular Cloning of the unc-54 and myo-123 MHC Genes. - 5. Immunological Identification of the Products of the myo-123 MHC Genes. - 6. Structural Organization of the Nematode MHC Genes. - 7. Molecular Anatomy of the Myosin Molecule. - 8. Sequences and Molecular Interpretation of unc-54 Mutations. - 9. Myosin Protein Expression and Mutagenesis in E. coli. - References. - 5. Small Cardioactive Peptides in A and B: Chemical Messengers in the Aplysia Nervous System. - 1. Introduction. - 2. The Distribution of SCP-Immunoreactive Neurons in the CNS. - 3. The SCP Gene and Precursor Protein. - 4. SCP Gene Expression. - 5. Subcellular Localization. - 6. Coexistence of Multiple Transmitters. - 7. Physiological Activities. - 8. Conclusions. - References. - 6. Molecular Biology Approach to the Expression and Properties of Mammalian Cholinesterases. - 1. Introduction: Expression of Cholinesterases as a Research SubjectScientific Significance Advantages and Difficulties. - 2. Expression of Cholinesterase mRNAs in Microinjected Xenopus Oocytes. - 3. Identification of Drosophila DNA Fragment that Hybridizes with Cholinesterase mRNA. - 4. Isolation and Partial Characterization of Human DNA Fragments Homologous to DroSR. - 5. Preparation of Synthetic Oligonucleotide Probes According to the Consensus Sequence at the Organophosphate-Binding Site. - 6. Preliminary Characterization of Neuroche cDNA Clones. - 7. Summary and Conclusions. - References. - 7. Genes and Gene Families Related to Immunoglobulin Genes. - 1. Introduction. - 2. Immunoglobulin Genes and the Immunoglobulin Domain. - 3. The T-Lymphocyte Cell-Surface Receptor for Antigen. - 4. Class I MHC Genes. - 5. Class II MHC Genes. - 6. Cell-Surface Receptors for Transepithelial Transport of Immunoglobulin. - 7. The T-Cell Accessory Molecules T4 and T8. - 8. Related Members of the Immunoglobulin Supergene Family Expressed in the Nervous System. - 9. Conclusion: The Evolution of the Immunoglobulin Super family. - References. - 8. Specificity of Prohormone Processing: The Promise of Molecular Biology. - 1. Introduction. - 2. Gene-Transfer Systems. - 3. Enzymatic Studies. - 4. The Internal Environment of Secretory Granules. - 5. Perspectives. - References. Language: English