I. Biomolecular Topology. - Tangle complexity and the topology of the Chinese rings. - Lattice invariants for knots. - Topology and geometry of biopolymers. - Energy functions for knots: beginning to predict physical behavior. - II. Biomolecular Structure and Dynamics: Theory. - The elastic rod provides a model for DNA and its functions. - Hamiltonian formulations and symmetries in rod mechanics. - Statistical mechanics of supercoiled DNA. - Determination of the DNA helical repeat and of the structure of supercoiled DNA by cryo-electron microscopy. - Dynamics of twist and writhe and the modeling of bacterial fibers. - III. Biomolecular Structure and Dynamics: Computation. - Integration methods for molecular dynamics. - On the parallelization of CHARMM on the CM-5/5E. - Computational studies of spatially constrained DNA. - Pursuing Laplace's vision on modern computers. Language: English