Vitamin B3 Niacin500 mg, 100 capsulesItem Catalog Number: 00372Many B vitamins are used in the body individually or in combination with enzymes to help release energy from carbohydrates, fat, and protein. Vitamin B coenzymes are crucial to the metabolic pathways that generate the energy needed by every cell in the body. Because they are codependent in their metabolic activities, a deficiency of one B vitamin can affect optimal functioning of organ systems throughout the body.1Niacin is the only B vitamin that can be synthesized in the liver from the amino acid tryptophan — on average, 1 mg of niacin can be synthesized from the ingestion of 60 mg of tryptophan.2-4 In its coenzyme forms, niacin is crucial to energy transfer reactions, particularly the metabolism of glucose, fat, and alcohol.5-6 Niacin’s beneficial effects on blood lipids is well-documented.7-19Supplement FactsServing Size 1 capsuleAmount Per ServingNiacin (vitamin B3)500 mgOther ingredients: gelatin, vegetable stearate.Non-GMODosage and UseTake one (1) capsule daily with meals, or as recommended by a healthcare practitioner.CautionTemporary flushing, itching, rash or gastric disturbances may occur. Liver function testing is recommended when niacin is taken in excess of 500 mg daily. Those with gout or liver diseases should avoid taking high doses of niacin.WarningsKEEP OUT OF REACH OF CHILDRENDO NOT EXCEED RECOMMENDED DOSEDo not purchase if outer seal is broken or damaged.When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.Ann N Y Acad Sci. 1980;355:80-97.Am J Clin Nutr. 1981 Mar;34(3):423-7.Am J Clin Nutr. 1980 Oct;33(10):2157-67.J Nutr. 1964 Mar;82:395-400.Mayo Clin Proc. 2008 Apr;83(4):470-8.Am J Cardiol. 2006 Feb 15;97(4):477-9.Arch Intern Med. 2002 Jul 22;162(14):1568-76.Arterioscler Thromb Vasc Biol. 2001 Nov;21(11):1783-9.JAMA. 2000 Sep 13;284(10):1263-70.Arch Intern Med. 2000 Apr 24;160(8):1177-84.Am J Cardiol. 2000 May 1;85(9):1100-5.Circulation. 1993 Jul;88(1):20-8.Am J Cardiol. 1998 Sep 15;82(6):737-43.JAMA. 1994 Mar 2;271(9):672-7.Neth J Med. 2004 Jul-Aug;62(7):229-34.J Clin Lipidol. 2012 Mar-Apr;6(2):121-31.Eur J Clin Pharmacol. 1991;40 Suppl 1:S49-S51.JAMA. 1990 Dec 19;264(23):3013-7.Am J Med. 2012 Oct;125(10):1026-35.