Melatonin IR/XR60 capsulesItem Catalog Number: 02201An estimated 50 to 70 million American adults have difficulty sleeping.1 Melatonin, known as the “sleep hormone,” is made naturally by your body primarily at night and is necessary to keep our day/night rhythm in tune, but those who have trouble sleeping may not be producing enough of it at the right time.2,3,4 Melatonin IR/XR helps you fall asleep and stay asleep all night long. It combines immediate-release and extended-release melatonin for approximately seven hours of healthy sleep support.More facts about Melatonin IR/XRLack of quality, restful sleep can affect cognitive health, metabolic health and more.5,6,7 Poor sleep can mean that you have trouble falling asleep, but it can also mean that you wake up in the middle of the night and can’t get back to sleep. If that sounds familiar, try Melatonin IR/XR.MicroActive® MelatoninEach capsule of Melatonin IR/XR contains 1.5 mg of MicroActive® Melatonin, a unique blend of immediate- and extended-release melatonin. Taken about 30 minutes before bed, Melatonin IR/XR helps you fall asleep quickly and stay asleep all night long. Just one Melatonin IR/XR capsule provides approximately seven hours of uninterrupted sleep support, so you sleep throughout the night.Clinical studies on standard immediate-release melatoninResults from an analysis of 15 clinical studies show that standard melatonin helps fall asleep faster and sleep longer and promotes sleep quality compared with a placebo.8 In one study, subjects took a 0.1 mg, 0.3 mg, or 3 mg melatonin capsule or a placebo 30 minutes before bedtime for three days. All three melatonin doses promoted restful sleep.9 In a recent randomized placebo-controlled trial, subjects who took 0.5 mg fast-release melatonin at night for four consecutive weeks fell asleep faster and experienced healthy, restful sleep compared with a placebo.10Clinical studies on controlled-release melatoninA study found that 2 mg of a controlled-release melatonin formulation taken two hours before bed promoted healthy sleep, compared with a placebo, and also shortened the length of time subjects spent awake after initially falling asleep.11 And in another randomized placebo-controlled study, subjects reported improvement in sleep quality after taking 2 mg of an extended-release formulation before bedtime.12Fall asleep, wake refreshedFor those who sometimes have difficulty sleeping and have tried other melatonin supplements to no avail, now there’s a new formulation from Life Extension. Get the quality, restful and uninterrupted sleep your body needs.Supplement FactsServing Size 1 capsuleAmount Per ServingMelatonin (as MicroActive®)1,5 mgOther ingredients: microcrystalline cellulose, gelatin (capsule), hydroxypropyl methylcellulose, sodium alginate, carnuba wax, silica.Non-GMOMicroActive® Melatonin is a registered trademark of Bioactives LLC.Dosage and UseTake one (1) capsule 30 to 60 minutes before bedtime, or as recommended by a healthcare practitioner. Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.CautionDo not consume alcohol, drive or operate machinery after taking this product.WarningsKEEP OUT OF REACH OF CHILDRENDO NOT EXCEED RECOMMENDED DOSEDo not purchase if outer seal is broken or damaged.When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.+ References Women's Health USA 2011. 2011;1(1):1.Br J Pharmacol. 2018;175(6):3190-99.Aging Dis. 2012;3(2):194-225.ScientificWorldJournal. 2012;2012:640389.Prog Cardiovasc Nurs. 2004;19(2):56-9.Neuropsychiatr Dis Treat. 2007;3(5):553-67.Obes Rev. 2009;10(Suppl 2):37-45.Sleep Med Rev. 2005;9(1):41-50.J Clin Endocrinol Metab. 2001;86(10):4727-30.PLoS Med. 2018;15(6):e1002587.Lancet. 1995;346(8974):541-4.Eur Neuropsychopharmacol. 2003;13(3):137-45.