GEROPROTECT® Stem Cell60 vegetarian capsulesItem Catalog Number: 02401Artificial Intelligence TechnologyTraditional clinical trials that evaluate nutrients for their ability to promote stem cell health are impractical because of the length of time required. To overcome this, Life Extension® partnered with Insilico Medicine, Inc., who used artificial intelligence to identify piceatannol from passion fruit, trans-resveratrol, and garcinol from kokum fruit from a database of ingredients tested in human cell lines to support stem cell health.Stem cells help rejuvenate your body by transforming into tissue-specific cells (called differentiation) and creating more stem cells (called self-renewal). But over time, stem cells tend to lose these unique properties. We’ve created GEROPROTECT® Stem Cell to help maintain youthful, healthy stem cell function.A healthy balance between these two actions promotes healthy tissue maintenance, growth, and longevity. But aging can cause stem cells to no longer function optimally—often losing the ability to self-renew, or differentiate into other cells, or both.1 We’ve created GEROPROTECT® Stem Cell to help maintain youthful, healthy stem cell function.Youthful stem cells help rejuvenate body tissues. This formula helps maintain stem cell balance, so they keep working as they should.Benefits at a Glance:Helps positively support healthy stem cell self-renewal and differentiationPromotes cell signaling pathways to support longevity, DNA health, and moreEncourages the body’s natural process for managing senescent stem cellsNutrients to encourage balanced stem cell healthGEROPROTECT® Stem Cell promotes youthful, healthy stem cell function and encourages balanced stem cell differentiation and self-renewal. It does so with nutrients that promote the cellular pathways that help maintain youthful stem cell behavior: a healthy, functional protein pool, DNA health, AMPK signaling, and more.These compounds were identified in partnership with Insilico Medicine, Inc., a machine learning company whose proprietary algorithm is based on 21st Century artificial intelligence computing techniques.Presveratrol™ proprietary blendPreservatrol™ is a proprietary blend of resveratrol and piceatannol, an extract of passion fruit. In vivo and in vitro studies indicate that piceatannol promotes stem cell differentiation as well as proteostasis—the quality control network that helps ensure the integrity of proteins within our cells.2-4Resveratrol is a phytonutrient with well-known benefits for longevity and health. In vivo and in vitro studies indicate that resveratrol has beneficial effects on stem cell health.6,7 Additionally, the combination of resveratrol and piceatannol promotes DNA health as well as encourages the body’s natural pathways for managing senescent stem cells.8Livinol™ kokum extract (garcinol)Garcinol is a compound derived from the kokum (garcinia indica) fruit. In vitro studies indicate that garcinol helps to positively regulate healthy stem cell self-renewal and differentiation.9-11 Garcinol inhibits an enzyme called histone acetyltransferase, or HAT. This enzyme is part of a process called histone acetylation—one of the main causes of stem cell aging and loss of function. By inhibiting this enzyme, garcinol helps restore youthful stem cell function and longevity. Combining cell supportGEROPROTECT® Stem Cell can be taken by itself, with our other GEROPROTECT® products or paired with our innovative Senolytic Activator formula for enhanced youthful cellular health support.Supplement factsServing Size 2 vegetarian capsulesAmount Per ServingLivinol™ kokum extract (fruit) [std. to 20% garcinol]500 mgPresveratrol™ Proprietary Blend [passion fruit extract (seed) (std. to 3.5% piceatannol) and Japanese knotweed extract (root) (std. to 98% trans-resveratrol)]378 mgOther ingredients: microcrystalline cellulose, cyclodextrin, vegetable cellulose (capsule), rice concentrate, silica.Non-GMODeveloped in collaboration with Insilico Medicine, Inc.Livinol™ is a trademark of Sabinsa Corporation.Dosage and UseTake two (2) capsules daily, or as recommended by a healthcare practitionerWarningsKEEP OUT OF REACH OF CHILDRENDO NOT EXCEED RECOMMENDED DOSEDo not purchase if outer seal is broken or damaged.When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.+ References Nat Med. 2014;20(8):870-80.Food Funct. 2016;7(10):4432-4441.Int J Mol Sci. 2018;19(7)Amino Acids. 2017;49(4):735-745.J Agric Food Chem. 2014;62(12):2541-8.J Cardiovasc Pharmacol. 2006;47(5):711-21.PLoS One. 2012;7(5):e37162.Cell Cycle. 2012;11(20):3851-60.J Nutr Biochem. 2018;54:140-150.PLoS One. 2011;6(9):e24298.J Agric Food Chem. 2011;59(3):1031-40