GEROPROTECT® Autophagy Renew30 vegetarian capsulesItem Catalog Number: 02415What Is GEROPROTECT Autophagy Renew?As we age, our bodies get less adept at autophagy, the process for recycling debris in our cells that get in the way of normal function. Give that cellular recycling process a helping hand—so you can live your longest, healthiest life. GEROPROTECT® Autophagy Renew contains a plant flavonoid, luteolin, and an alkaloid from pepper called piperlongumine, which support your body’s natural clean-up process.Give your body’s natural cellular recycling process a boost—so you can live your longest, healthiest life.Benefits at a Glance:Innovative longevity formulaHelps your body function optimally, without cellular debris getting in the wayPromotes healthy AMPK activityEncourages cells to recycle waste materialHelps maintain cellular energy balanceRecycling what’s inside: autophagy explainedWe know that recycling is good for the environment. But as it turns out, it’s also good for our cells: autophagy is a natural process by which cells clean up intra-cellular debris and other metabolic waste. Tiny cellular organelles called lysosomes breakdown and repurpose this spent material. So why does cellular autophagy matter? Because it helps our bodies conserve energy and function properly, which is essential to living a long, healthy life.Without autophagy, the insides of our cells would become cluttered and eventually cease to function. The problem is autophagy naturally decreases over time. But the right nutrients can encourage youthful, healthy autophagy at the cellular level—the hard part is figuring out which nutrients do the best job.Insilico Artificial IntelligenceGEROPROTECT® Autophagy Renew was created through a partnership with Insilico Medicine, Inc., who used their database of studies on geroprotectors to identify luteolin from Japanese sophora flower for its ability to promote autophagy—effects that are also supported by several pre-clinical studies.We added piperlongumine (a pepper alkaloid) because of our own extensive scientific review. Together, these nutrients have the potential to encourage healthy cellular autophagy—and with it, longevity.LuteolinLuteolin is a flavonoid present in fruits, vegetables and nutritious herbs. We get trace amounts of luteolin in our diets, but not nearly enough to encourage healthy cellular renewal. GEROPROTECT® Autophagy Renew contains 165 mg of luteolin per serving. In pre-clinical studies, luteolin promoted autophagy, leading to a variety of health benefits, particularly in the brain.1Luteolin supports the cellular pathways that encourage autophagy, such as AMPK signaling.2 Luteolin also promotes the generation of new lysosomes, the "recycling plants" inside your cells that break down waste.2 Plus, luteolin inhibits the processes that discourage autophagy, such as mTOR signaling—a central regulator of cellular metabolism and proliferation.2PiperlonguminePiperlongumine is a biologically active alkaloid found in pepper plants. In pre-clinical studies, piperlongumine was shown to activate autophagy as indicated by increased cellular markers called LC3-autophagosomes, structures involved in initiation of autophagy within a cell.3,4Piperlongumine activates Beclin-1, a gene that triggers formation of these autophagosome structures.5Beclin-1 dependent autophagy helps protect delicate mitochondria and helped inhibit inflammation to support cardiovascular health in an animal study.5 Our formula contains 10 mg of piperlongumine.Take alone or with Senolytic ActivatorWhile cellular housekeeping orchestrated by autophagy is a different process than the ones that govern the removal of senescent cells, they are complementary. Therefore, GEROPROTECT® Autophagy Renew can be taken alone, or in conjunction with our Senolytic Activator formula.Supplement factsServing Size 1 vegetarian capsuleAmount Per ServingLuteolin [from Japanese sophora (flower buds)]165 mgPiperlongumine [from long pepper (root)]10 mgOther ingredients: maltodextrin, vegetable cellulose (capsule), vegetable stearate, silica.†Developed in collaboration with Insilico Medicine, IncNon-GMODosage and UseTake one (1) capsule daily, or as recommended by a healthcare practitioner.WarningsKEEP OUT OF REACH OF CHILDRENDO NOT EXCEED RECOMMENDED DOSEDo not purchase if outer seal is broken or damaged.When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.+ References Brain Res. 2014;1582:237-46. Insilico Medicine - Data on File Autophagy. 2018;14(5):845-861. Br J Cancer. 2014;110(4):899-907. Circulation. 2018;138(20):2247-2262.