The active ingredients (Gynostemma pentaphyllum) and citrus flavonoid hesperidin) in AMPK Metabolic Activator activate AMPK enzyme which helps reduce unwanted abdominal fat, by targeting this kind of fat specifically for cellular energy production, thereby reducing belly fat. Why it Works: One might think that all body fat is the same, but in fact specific types of body fat causes greater health concerns than others. One of the worst kinds of fat is belly fat. Belly fat can actually escalate various natural aspects of the aging process that takes place in the body [1]. This is because abdominal fat can create compounds that may cause inflammation and oxidative stress [2]. AMPK is an enzyme found in each and every cell in your body. As a result of natural aging, AMPK levels are lowered, which is a major cause of increased amounts of unwanted belly (abdominal) fat. However, studies show that increasing AMPK activity can encourage the cells to stop storing fat and start using it to produce energy instead. AMPK Metabolic Activator has two powerful ingredients (ActivAMP® (Gynostemma pentaphyllum) and citrus flavonoid hesperidin) which it uses to trigger the AMPK enzyme [2,3]. This in turn causes the body to start burning unwanted abdominal fat [4,5]. This is because the increased levels of AMPK enzyme is telling the body to stop storing belly fat and instead use it to create ATP, the main source of energy for cells. Furthermore, it also helps maintain cholesterol levels already within the normal range and also promotes the vascular function. The Science Behind the Product: Gynostemma pentaphyllum, or jiaogulan, is a plant used in traditional Asian medicine for longevity promotion, and is distantly related to the cucumber [7]. Today, scientists have uncovered the reason why Asian doctors prescribed G. pentaphyllum to inhibit various age-related health issues; the reason is that it promotes AMPK activation [6, 8]. Not only does G. pentaphyllum activate AMPK, but it also transport excess fats into the mitochondria, which are the “powerhouses” of the cell. Here it is utilized for energy production [8]. This results in a highly efficient cellular energy production and therefore a sharp reduction in unnecessary fat storage. Furthermore, extracts of G. pentaphyllum have other beneficial properties. This includes the ability to prolong the lives of cells which are put under pressure from stresses induced by oxidation and fat accumulation [9,10]. Studies have confirmed what researchers found in lab research: G. pentaphyllum boosts AMPK activity and also provides important longevity benefits. Hesperidin is a flavonoid naturally found in citrus fruits. Large studies associate increased consumption of flavonoid-rich foods, such as citrus, with reduced risk for cardiovascular problems. Hesperidin has been shown to promote AMPK activation, help regulate inflammatory factors and support blood vessel function [11, 12]. Thus, hesperidin complements G. pentaphyllum to modulate abdominal fat distribution. How to Use: Take one (1) tablet daily, with or without food, or as recommended by a healthcare practitioner.