Life Extension 7116 01658

Ginkgo Biloba Certified Extract™120 mg, 365 vegetarian capsulesItem Catalog Number: 01658Ginkgo biloba is one of the oldest trees known and has been used to support health for nearly 2,800 years. Ginkgo has been found to:Support healthy circulation1,2Help maintain the normal function and tone of blood vessels3-6Support healthy oxygen and glucose metabolism in the brain7-11Stabilize capillaries and make them less fragile12-14Support normal coagulation of blood15,16Support healthy aging in the brain17-21Ginkgo leaf extracts contain several active constituents with neuroprotective and cardioprotective properties. These include flavonoids (e.g., rutin, quercetin, kaempferol, and proanthocyanidins), terpenoids (i.e., ginkgolides), and organic acids. Flavonoids are known to strengthen capillaries, promote healthy blood flow to the brain, and help maintain cognitive health.22-26Flavonoids such as quercetin and kaempferol from Ginkgo biloba are potent antioxidants and scavengers of many species of free radical, protecting against oxidative cell damage.27 Ginkgo protects the energy-producing mitochondria in the cells, thus enhancing oxygen utilization and cellular respiration.18In a study to determine whether ginkgo extract could inhibit age-associated cellular changes, the brain and liver mitochondria of old mice fed ginkgo extract in their drinking water was compared to those of young and old control mice. Mitochondria from the mice given ginkgo exhibited significantly less genetic damage, peroxide generation, and oxidation of the crucial antioxidant glutathione than non-supplemented mice. In addition, mitochondria from old mice given the ginkgo extract resembled those of young mice much more closely, being similar in size and morphology. The study concluded that standardized ginkgo extract inhibits age-related decline in mitochondrial structure and function by protecting mitochondria from oxidative damage.28The premium-quality botanical extract in Ginkgo Biloba Certified Extract™ has been concentrated and dual-standardized to ensure the highest quality, consistency, and biological activity.The phytonutrient profile of Ginkgo Biloba Certified Extract™ is comparable to the GBE 24/6 extract used in clinical studies worldwide and monographed in German Commission E. The health regulatory agency that regulates ginkgo purity in Germany mandates that ginkgo not contain more than 5 ppm of ginkgolic acid. Ginkgo Biloba Certified Extract™ contains less than 1 ppm of ginkgolic acid. Ginkgolic acid is a substance related to anacardic acid (poison ivy) and may cause an allergic reaction in some people. Ginkgo Biloba Certified Extract™ has one of the lowest ginkgolic acid levels commercially available.Ginkgo Biloba Certified Extract™ has high levels of ginkgolide B (>1%), which is the most studied terpene lactone and thought to be a major regulator of platelet activating factor (PAF). PAF is a powerful physiologic-response mediator for many processes.29-33Supplement FactsServing Size 1 vegetarian capsuleAmount Per ServingGinkgo biloba (leaf) extract [std. for 24% ginkgo flavone glycosides, 6% total terpene lactones, 120 mgOther ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, stearic acid.Non-GMODosage and UseTake one (1) capsule daily with or without food, or as recommended by a healthcare practitioner.CautionIf you are taking anticoagulant or antiplatelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.WarningsKEEP OUT OF REACH OF CHILDRENDO NOT EXCEED RECOMMENDED DOSEDo not purchase if outer seal is broken or damaged.When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.Phytother Res. 2008 Jun;22(6):734-9.Phytomedicine. 2008 Mar;15(3):164-9.Clin Physiol Funct Imaging. 2002 Nov;22(6):375-8.Wilderness Environ Med. 2007 Winter;18(4):251-7.J Pharm Pharmacol. 2006 Feb;58(2):243-9.Asian J Androl. 2011 Sep;13(5):742-6.Neuroscience. 2007 Jan 5;144(1):217-22.Clin Chim Acta. 2004 Feb;340(1-2):153-62.Acta Pharmacol Sin. 2008 Sep;29(9):1042-50.J Nat Med. 2011 Jan;65(1):50-6.Pharmacopsychiatry. 2003 Jun;36 Suppl 1:S89-S94.Phytomedicine. 2007 Feb;14(2-3):196-203.Acta Pharmacol Sin. 2004 Oct;25(10):1306-11.Clin Nutr. 2004 Aug;23(4):615-21.Clin Lab Haematol. 2003 Aug;25(4):251-3.Thromb Res. 2009 Jul;124(3):328-34.Altern Ther Health Med. 2001 Sep-Oct;7(5):70-86, 88-90.Platelets. 2010;21(5):373-9.Adv Ther. 1998 Jan-Feb;15(1):54-65.Acta Neurobiol Exp (Wars). 2009;69(2):217-31.Pharmacopsychiatry. 2010 May;43(3):86-91.J Chromatogr A. 2009 Mar 13;1216(11):2002-32.Drugs R D. 2003;4(3):188-93.Wien Med Wochenschr. 2007;157(13-14):295-300.Arzneimittelforschung. 2007;57(1):4-11.Rev Prat. 2000 Jun 1;50(11):1195-8.Planta Med. 2009 Jun;75(8):792-6.Pharmacol Res. 2007 Dec;56(6):493-502.Pharmacol Res. 2002 Dec;46(6):565-8.Adv Ther. 1998 Jan-Feb;15(1):54-65.Chem Biol