Dose-Response Analysis Using R

Nowadays the term dose-response is used in many different contexts and many different scientific disciplines including agriculture biochemistry chemistry environmental sciences genetics pharmacology plant sciences toxicology and zoology. In the 1940 and 1950s dose-response analysis was intimately linked to evaluation of toxicity in terms of binary responses such as immobility and mortality with a limited number of doses of a toxic compound being compared to a control group (dose 0). Later dose-response analysis has been extended to other types of data and to more complex experimental designs. Moreover estimation of model parameters has undergone a dramatic change from struggling with cumbersome manual operations and transformations with pen and paper to rapid calculations on any laptop. Advances in statistical software have fueled this development. Key Features: Provides a practical and comprehensive overview of dose-response analysis. Includes numerous real data examples to illustrate the methodology. R code is integrated into the text to give guidance on applying the methods. Written with minimal mathematics to be suitable for practitioners. Includes code and datasets on the bookâs GitHub: https://github. com/DoseResponse. This book focuses on estimation and interpretation of entirely parametric nonlinear dose-response models using the powerful statistical environment R. Specifically this book introduces dose-response analysis of continuous binomial count multinomial and event-time dose-response data. The statistical models used are partly special cases partly extensions of nonlinear regression models generalized linear and nonlinear regression models and nonlinear mixed-effects models (for hierarchical dose-response data). Both simple and complex dose-response experiments will be analyzed. . Language: English