What do we not bioenergetics? A general view on the state of the art. - I: Bioenergetics of mitochondria: In vitro and in vivo studies. - Top-down elasticity analysis and its application to energy metabolism in isolated mitochondria and intact cells. - A model of O2- generation in the complex III of the electron transport chain. - Quantitative analysis of some mechanisms affecting the yield of oxidative phosphorylation: Dependence upon both fluxes and forces. - Oxidative phosphorylation in intact hepatocytes: Quantitative characterization of the mechanisms of change in efficiency and cellular consequences. - Yeast mitochondrial metabolism: From in vitro to in situ quantitative study. - Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo. - Cytoskeleton and mitochondrial morphology and function. - Energetics of swelling in isolated hepatocytes: A comprehensive study. - II: Energy transfer networks: Molecular physiology of kinases lessons from transgenic mice mathematical theories. - Functional aspects of the X-ray structure of mitochondrial creatine kinase: A molecular physiology approach. - Oligomeric state and membrane binding behaviour of creatine kinase isoenzymes: Implications for cellular function and mitochondrial structure. - Molecular characterization of the creatine kinases and some historical perspectives. - Adenylate kinase: Kinetic behavior in intact cells indicates it is integral to multiple cellular processes. - Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies. - In situ measurements of creatine kinase flux by NMR. The lessons from bioengineered mice. - Mathematical model of compartmentalized energy transfer: Its use for analysis and interpretation of31P-NMR studies of isolated heart of creatine kinase deficient mice. - Functional coupling of creatine kinases in muscles: Species and tissue specificity. - Theoretical modelling of some spatial and temporal aspects of the mitochondrion/creatine kinase/myofibril system in muscle. - Quantitative studies of enzyme-substrate compartmentation functional coupling and metabolic channelling in muscle cells. - III: Metabolic signalling and calcium: Regulation of mitochondrial oxidative phosphorylation in vivo. - Subtleties in control by metabolic channelling and enzyme organization. - The dynamic regulation of myocardial oxidative phosphorylation: Analysis of the response time of oxygen consumption. - Is it possible to predict any properties of oxidative phosphorylation in a theoretical way?. - Role of mitochondrial calcium transport in the control of substrate oxidation. - Modulation of cell calcium signals by mitochondria. - IV: Bioenergetics and medicine. - Mitochondrial function as a determinant of recovery or death in cell response to injury. - Role of cellular energetics in ischemia-reperfusion and ischemic preconditioning of myocardium. - Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: A potential cause for altered energy transfer in cardiac muscle?. - Metabolic control analysis and mitochondrial pathologies. - Mechanisms of thyroid hormone control over sensitivity and maximal contractile responsiveness to ?-adrenergic agonists in atria. - Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: Down-regulation of the expression of creatine transporter isoforms in skeletal muscle. - Clinical cardiac magnetic resonance spectroscopypresent state and future directions. - Time-Resolved Spectroscopyof mitochondria cells and tissues under normal and pathological conditions. - Index to Volume 184. Language: English